It is possible that the cause is due to alterations in some of your genes, that is, the pharmacogenetics.

Medicines or drugs constitute one of the great advances of humanity and must be cannot be renounced although in many cases they produce adverse effects but in in many cases it is not the medicines that are to blame and the alterations may be of some genes that most people possess to a greater or lesser degree without knowing it. Knowledge of these alterations is called pharmacogenetics.


ASPAFAR is an Association of Patients and through On our website WWW.ASPAFAR.COM you can find out about our purposes. Connect and express your doubts, concerns, opinions, etc. in our forum "WWW.FOROASPAFAR.COM".

Most of those who suffer from these disorders They ignore it and therefore we invite you to enter our FORUM, where we can help you know if pharmacogenetics is the cause of your problems with medicines or drugs and know other people's testimonies with your same doubts and concerns.

Most primary care doctors, incomprehensibly, they don't have enough knowledge to help you, especially since this topic belongs to the world of pharmacology.


Pharmacogenetics is a new discovery for us, it is not an esoteric concept, it is not a rare disease and it is not science fiction.

Pharmacogenetics is:

-It is a science within the field of Human Health, basic and applied, which arises in the 60s of the last century. Your applications practices are based on clinical analysis of blood or cell samples yugales (insides of the cheeks) of genetic changes in the sequence of DNA that are responsible for the different response that we have individuals against the same drug. It is a science that has developed rapidly due to technological advances derived from the Human Genome Project and as a discipline it is already studied in some Faculties of Pharmacy and Medicine of our country.

-That these variations are one of the most frequent preventable causes of the appearance of effects adverse events, including death of the person. And also on occasions of lack response to treatments.

-That their alterations hinder the metabolization of drugs and other substances such as nutrients essential, food, supplements, that is, the transformation of fat-soluble into water-soluble to be able to be expelled from our body producing accumulation and consequently producing over or under dosage. -That for various causes, has been incomprehensibly addressed with long delay.

-That there are international organizations such as the NIH, FDA, PGRN, DPWG and nationals such as SEFF, AEMPS that are working to generate the necessary knowledge in this matter and publish by the Drug Regulatory Agencies, recommendations on the use of these Genetic Biomarkers in certain medications to reduce the effects and optimize the response to them (here it is necessary to say what means each acronym ex NIH = National Institutes of Health-USA, FDA = Food and Drug Administration, AEMPS = Agency Española del Medicamentos y Productos Sanitarios DPWG = Dutch Pharmacogenetic Working Group. PGRN = Pharmacogenomic Research Network, one could also briefly explain what each of these organisms does)

-That in various pathologies, especially the oncology, new concepts are already being applied in order to optimize pharmaceutical treatments, constituting one of the main advances about cancer.

-That the adverse effects of medicinal origin have been the 4th-6th cause of death in the USA with 106,000 deaths. (Jason Lazarou, MSc; Bruce H. Pomeranz, MD, PhD; Paul N. Corey, PhD. Incidence of Adverse Drug Reactions in Hospitalized Patients A Meta-analysis of Prospective Studies JAMA. 1998; 279 (15): 1200-1205. doi: 10.1001 / jama.279.15.1200)


USA has always been at the head in research on PHARMACOGENETICS. In that country, the estate pharmacist is responsible for its optimization and even care primary.

As a sample a pamphlet that we reproduce here, distributed by the prestigious or CPIC in 2005 where it was intended to inform the inhabitants of that country and even to Spanish-speaking people about the nature of PHARMACOGENETICS.