DO THE MEDICINES MAKE YOU FEEL BAD?
It is possible that the cause
is due to alterations in some of your genes, that is, the
pharmacogenetics.
Medicines or drugs
constitute one of the great advances of humanity and must be
cannot be renounced although in many cases they produce adverse effects but in
in many cases it is not the medicines that are to blame and the alterations may be
of some genes that most people possess to a greater or lesser degree
without knowing it. Knowledge of these alterations is called pharmacogenetics.
ASPAFAR is an Association of Patients and through
On our website WWW.ASPAFAR.COM you can find out about our purposes. Connect and
express your doubts, concerns, opinions, etc. in our forum
"WWW.FOROASPAFAR.COM".
Most of those who suffer from these disorders
They ignore it and therefore we invite you to enter our FORUM, where we can
help you know if pharmacogenetics is the cause of your problems with
medicines or drugs and know other people's testimonies with your
same doubts and concerns.
Most primary care doctors,
incomprehensibly, they don't have enough knowledge to help you,
especially since this topic belongs to the world of pharmacology.
Pharmacogenetics is a new discovery for us,
it is not an esoteric concept, it is not a rare disease and it is not science fiction.
Pharmacogenetics is:
-It is a science within the field of Human Health, basic
and applied, which arises in the 60s of the last century. Your applications
practices are based on clinical analysis of blood or cell samples
yugales (insides of the cheeks) of genetic changes in the sequence
of DNA that are responsible for the different response that we have
individuals against the same drug. It is a science that has developed
rapidly due to technological advances derived from the Human Genome Project and
as a discipline it is already studied in some Faculties of Pharmacy and Medicine of
our country.
-That these variations
are one of the most frequent preventable causes of the appearance of effects
adverse events, including death of the person. And also on occasions of lack
response to treatments.
-That their
alterations hinder the metabolization of drugs and other substances such as nutrients
essential, food, supplements, that is, the transformation of fat-soluble into water-soluble to be able to be expelled from
our body producing accumulation and consequently producing over
or under dosage.
-That for
various causes, has been
incomprehensibly addressed with long delay.
-That there are international organizations such as the
NIH, FDA, PGRN, DPWG and nationals such as SEFF, AEMPS that are working to generate the necessary knowledge in this matter and publish by the
Drug Regulatory Agencies, recommendations on the use of
these Genetic Biomarkers in certain medications to reduce the effects
and optimize the response to them (here it is necessary to say what
means each acronym ex NIH = National
Institutes of Health-USA, FDA = Food and Drug Administration, AEMPS = Agency
Española del Medicamentos y Productos Sanitarios DPWG = Dutch Pharmacogenetic
Working Group. PGRN = Pharmacogenomic Research Network, one could also
briefly explain what each of these organisms does)
-That in various pathologies, especially the
oncology, new concepts are already being applied in order to optimize
pharmaceutical treatments, constituting one of the main advances
about cancer.
-That the adverse effects of medicinal origin have been the
4th-6th cause of death in the USA with 106,000 deaths. (Jason Lazarou, MSc;
Bruce H. Pomeranz, MD, PhD; Paul N. Corey, PhD. Incidence of Adverse Drug
Reactions in Hospitalized Patients A Meta-analysis of Prospective Studies JAMA. 1998; 279 (15): 1200-1205.
doi: 10.1001 / jama.279.15.1200)
USA has always been at the
head in research on PHARMACOGENETICS.
In that country, the estate
pharmacist is responsible for its optimization and even care
primary.
As a sample a
pamphlet that we reproduce here, distributed by the prestigious Nigms.nih.gov or
CPIC in 2005 where it was intended to inform the inhabitants of that country and
even to Spanish-speaking people about the nature of PHARMACOGENETICS.
