When is a pharmacogenetic analysis necessary?

In which person might it be necessary or advisable to perform a clinical analysis of pharmacogenetic variations that influence the response to a prescribed treatment?

A good option (it is not the only one) is to check if the drug (s) we are using is find in any of the GuidesClinics of International Research Organizations in Pharmacogenetics used by professionals in the field, the mostused are: CPIC Guidelines (Clinical Pharmacogenetics Implementation Consortium) and DPWG (Dutch Pharmacogenomic working group) containing information and recommendations for analysis of genetic variations in response genes drugs as well as indications for management
(adjustment of drug concentrations or recommendations forsubstitution with another drug).

It is provided to below both guides, indicating the drug and the gene to be analyzed in each one
of it. It must be borne in mind that the name of the drug refers to the active principle and not to the commercial name, in which the same principle can be marketed under different names commercials or presentations

DPWG GUIDES

· Abacavir y HLA-B

· Acenocoumarol y CYP2C9-VKORC1

· Amitriptyline y CYP2D6

· Aripiprazole y CYP2D6

· Atomoxetine y CYP2D6

· Azathioprine y TPMT

· Capecitabine y DPYD

· Carvedilol y CYP2D6

· Citalopram y CYP2C19

· Clomipramine y CYP2D6

· Clopidogrel y CYP2C19

· Clozapine y CYP2D6

· Codeine y CYP2D6

· Doxepin y CYP2D6

· Duloxetine y CYP2D6

· Escitalopram y CYP2C19

· Esomeprazole y CYP2C19

· Flecainide y CYP2D6

· Fluorouracil y DPYD

· Flupenthixol y CYP2D6

· Glibenclamide y CYP2C9

· Gliclazide y CYP2C9

· Glimepiride y CYP2C9

· Haloperidol and CYP2D6

· Contraceptivos orales de uso sistémico y F5

· Imipramine y CYP2C19-CYP2D6

· Irinotecan y UGT1A1

· Lansoprazole y CYP2C19

· Mercaptopurine y TPMT

· Metoprolol y CYP2D6

· Mirtazapine y CYP2D6

· Moclobemide y CYP2C19

· Nortriptyline y CYP2D6

· Olanzapine y CYP2D6

· Omeprazole y CYP2C19

· Oxycodone y CYP2D6

· Pantoprazole y CYP2C19

· Paroxetine y CYP2D6

· Fenprocoumon y CYP2C9-VKORC1

· Fenitoina y CYP2C9

· Propafenone y CYP2D6

· Rabeprazole y CYP2C19

· Ribavirina y HLA-B

· Risperidona y CYP2D6

· Sertralina y CYP2C19

· Tacrolimus y CYP3A5

· Tamoxifen y CYP2D6

· Tegafur y DPYD

· Tioguanina y TPMT

· Tolbutamide y CYP2C9

· Tramadol y CYP2D6

· Venlafaxina y CYP2D6

· Voriconazol y CYP2C19

· Zuclopenthixol y CYP2D6

GCPIC GUIDES

· Abacavir y HLA-B

· Alopurinol y HLA-B

· Volatile anesthetics :Desflurano,Enflurano,Halotano,Isoflurano,Metoxiflurano,Sevoflurano,

Succinilcolina y RYR1-CACNA15

· non-steroidal anti-inflammatory drugs :

Aspirina,Diclofenaco,Celecoxib,Flurbiprofeno,Aceclofenaco,Ibuprofeno,Indometacina,

Lornoxicam,Lumiracoxib,meloxicam, metamizol, Nabumetona, Naproxeno, Piroxicam, Tenoxicam y CYP2C9-CYP2C8

· Amitriptilina y CYP2C19-CYP2D6

· Atazanavir y UGT1A1

· Azatioprina y TPMT-NUDT15

· Capecitabina y DPYD

· Carbamazepina y HLA-A

· Citalopram y CYP2C19

· Clomipramina y CYP2C19-CYP2D6

· Clopidogrel y CYP2C19

· Codeina y CYP2D6

· Desipramina y CYP2D6

· Dexlansoprazol y CYP2C10

· Doxepina y CYP2D6

· Efavirez y CYP2B6

· Escitalopram y CYP2C19

· Fluorouracilo y DPYD

· Fluvoxamina y CYP2D6

· Imipramina y CYP2D6 y CYP2C19

· Ivacaftor y CFTR

· Mercaptopurina y TPMT-NUDT15

· Nortriptilina y CYP2D6

· Ondasetron y CYP2D6

· Oxcarbamazepina y HLA-B

· Paroxetina y CYP2D6

· Fenitoina y CYP2C9 –HLA-B

· Rasburicasa y G6PD

· Rivabirina y IFNL3

· Sertralina y CYP2C19

· Simvastatina y SLCO1B1

· Tacrolimus y CYP3A5

· Tegafur y DPYD

· Tioguanina y TPMT-NUDT15

· Trimipramina y CYP2C19-CYP2D6

· Tropisetron y CYP2D6

· Voriconazol y CYP2C19

· Warfarina y CYP2C9-CYP4F2-VKORC1

Dr. Andrés Corno.